| 598. Silk-E The People's Champ aka Sherri Stack-A-Grip | Background Vocals | 1 |
| 598. Silvia Estrada | Guitarrón | 1 |
| 598. Sima Cunningham | Guitar, Vocals | 1 |
| 598. Simba | Bass | 1 |
| 598. Simba Scott | Bass | 1 |
| 598. Simeon Jones | Keys | 1 |
| 598. Simon Andermo | Auxiliary Percussion, Bass | 1 |
| 598. Simon Demouveaux | Banjo, Oud (France) | 1 |
| 598. Simon LeSaint | Drums, Vocals | 1 |
| 598. Simon Mavin | Keys | 1 |
| 598. Simon Siala | Bass | 1 |
| 598. Simon Söfelde | Drums | 1 |
| 598. Simone Dinnerstein NPR | Featured Artist | 1 |
| 598. Simone Odaranile | Drums | 1 |
| 598. Sinkane | Featured Artist | 1 |
| 598. Sister Sparrow & The Dirty Birds | Featured Artist | 1 |
| 598. Sita Chay | Violin | 1 |
| 598. Sixpence None the Richer | Featured Artist | 1 |
| 598. Siyabonga Hosana Magagula | Bass, Synth | 1 |
| 598. Skinny Lister | Featured Artist | 1 |
| 598. Skip McDonald | Guitar | 1 |
| 598. Skrillex | DJ, Guitar, Samples | 1 |
| 598. Sleepy Brown | Vocals | 1 |
| 598. Slom | Music Director | 1 |
| 598. Sloppy Jane | Featured Artist | 1 |